Persistant polyclonal lymphocytosis (PPLB)

Persistent polyclonal B-cell lymphocytosis.

Persistent polyclonal B-cell lymphocytosis (PPBL) is a rare and recently described entity. PPBL is diagnosed predominantly but not exclusively in women, usually smokers and is characterized by a moderate, chronic and absolute lymphocytosis (> 4 x 109/L). Peripheral blood examination show in all cases atypical binucleated lymphocytes. A polyclonal serum IgM is also associated and HLA-DR7 express...

Persistent polyclonal B-cell lymphocytosis.

We document a case of persistent lymphocytosis in which the characteristic binucleated circulating lymphocytes were shown immunologically to be polyclonal B-cells. Cytogenetic and molecular studies failed to show a clonal population. A review of the literature on this rare condition, persistent polyclonal B-cell lymphocytosis, highlights an association with the female sex, HLA-DR7 antigen, smok...

Polyclonal B Lymphocytosis with Binucleated Lymphocytes (PPBL)

Bilobulated circulating lymphocytes in persistent polyclonal B-cell lymphocytosis.

Correspondence: Lourdes Florensa, MD, Laboratori de Citologia Hematològica, Laboratori de Referència de Catalunya, Hospital de l’Esperança, Av. Sant Josep de la Muntanya 12, 08024 Barcelona, Spain. Phone: international +34-93-285.02.00 ext 2189-2243 – Fax: international +34-93-210.84.06 – E-mail: [email protected] A44-year-old female was referred for investigation of a 10-year persistent lymph...

Persistent polyclonal lymphocytosis in human immunodeficiency virus-1-infected patients.

In this study we describe the clinical, morphologic, immunologic, and genetic features of a chronic peripheral blood lymphocytosis associated with posttraumatic splenectomy in patients with human immunodeficiency virus-1 (HIV-1) infection. Among a series of 2,365 consecutive HIV-1 seropositive cases investigated, eight patients were selected for the presence of more than 4,000 lymphocytes/mm3. ...